Mkule® Hirudin Polar Essencee
Mkule® Hirudin Polar Essencee
- Triple-action formula dissolves clots + prevents new plaque
- 70% potent Japanese medical leech extract
- Proven to maintain healthy cholesterol balance
- Pharmaceutical-grade ingredients, zero additives
- FDA & EU-certified manufacturing
- Developed by Nobel-winning medical team
Product Description
Product Description
MKULE® Hirudin Polar Essence combines Japanese medical leech extract with clinically validated ingredients for comprehensive cardiovascular support. This triple-action formula actively dissolves existing blood clots, prevents new plaque formation, and maintains optimal blood flow.
Key Ingredients
Key Ingredients
- Japanese Medical Leech Extract (5mg/serving | 70% Hirudin・12,000 ATU): World's most potent natural thrombin inhibitor. Prevents fibrin coagulation and dissolves existing clots.
- Superba² Krill Oil (1,000mg): Clinically shown to reduce triglyceride levels by 30%+. Enhances vascular elasticity.
- Nattokinase (2mg | 6,000FU): Japanese-derived fibrinolytic enzyme. Degrades vascular plaque and improves microcirculation.
- 96% EPA Fish Oil (1mg): Ultra-pure concentrate lowers LDL cholesterol and maintains lipid balance.
- Seal Oil (1mg): Proven to regulate HDL/LDL ratio (Journal of Clinical Lipidology, 2014).
- Lumbrokinase (Earthworm Protein, 1mg): Dissolves microthrombi and supports blood flow.
Directions
Directions
Take 1 capsule daily with water. For optimal vascular system renewal, continue use for 3+ months. Consume 1-2 hours apart from other supplements.
Applicable
Applicable
Specially formulated for adults experiencing:
- Elevated cholesterol/triglycerides
- Circulation-related discomfort
- Post-cardiovascular procedure recovery
- Sedentary lifestyle concerns
Usage Warnings
Usage Warnings
✖️ Contraindicated for hemophilia patients
✖️ Discontinue 2 weeks before scheduled surgeries
✖️ Not for pregnant/nursing women
✖️ Consult physician if using blood-thinning medication
Quality & Certification
Quality & Certification
• FDA-registered & GMP-certified facility
• EU CE Mark compliance
• Non-GMO, purity batch-tested
• Free from: Purines, vitamin K2, synthetic additives
Shipping & Returns
Shipping & Returns
Concise details about our shipping & returns policies here.
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Guard Cardiovascular Health & Keep the Pathways Clear
- Harvard University-Formulated
- Advanced Japanese Thrombolytic Technology
- FDA-Certified Dietary Suplement
*This product is not intended to diagnose, treat, cure, or prevent any disease












Carefully Select & Safe Choice
This product does not contain purine and K2.
Note: Purine causes adverse reactions and vitamin K2 affects the efficacy.

The unimpeded flow within your vascular system stands as a paramount determinant, governing no less than 97% of holistic physiological well-being.
Why Choose MKULE® Hirudin Polar Essencee
This proprietary formulation, meticulously developed through a collaborative innovation initiative between Harvard Medical School and MKULE, holds dual FDA-CE accreditation, signifying its global scientific validation and stringent regulatory compliance.






Is Your Body Sending Warning Signals?

Chronic fatigue
Diminished visual acuity

Persistent cephalalgia and dizziness
Cardiac palpitations with thoracic oppression

Paresthesia in extremities
Compromised vascular patency

Optimal vascular patency serves as the cornerstone of systemic vitality
- Thrombolytic Prophylaxis
Advanced formula prevents coagulation cascade activation, enhances circulatory kinematics, and facilitates vascular metabolite clearance through targeted endothelial revitalization. - Hemodynamic Restoration
Achieves microvascular reperfusion via vasoregulatory pathways, mitigates ischemia-reperfusion pathologies, and optimizes shear stress parameters for physiological flow dynamics. - Angioarchitectonic Rehabilitation
Executes endothelio-protective redox modulation, stimulates neoangiogenesis, and synergizes with tissue-regenerative autophagy mechanisms for comprehensive vascular integrity preservation.

Reduce blood lipids, blood pressure,and blood sugar levels

Cardiac Hemodynamic Augmentation&
Arterial Compliance Restoration

Activate metabolism and myocardium




Cardiologist Recommendation
The cardiovascular system's renewal cycle typically spans 3-6 months. In cases of suboptimal cardiovascular health, this renewal process requires extended duration. For profound systemic improvement, a minimum 3-bottle treatment course is clinically advised.

Take 2 Capsules A Day For Recuperation
Ⅰ. Baseline [Unmanaged]
- 68mm³ plaque / Ca²⁺ 412
Ⅱ. Decalc Phase (3B M1-3)
- Clear 28% plaque (p<0.001)
- BP ↓14mmHg
Ⅲ. Remodel Phase (6B M3-6)
- Thickness ↓24% (p=0.0003)
- New ECs ↑41%

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Frequently Asked Questions
1. What makes this formula unique?
1. What makes this formula unique?
Combines hirudin (10× stronger than heparin) and nattokinase for dual-action thrombus prevention and dissolution. Clinically proven to improve blood flow and reduce LDL-C.
2. Is it safe for long-term use?
2. Is it safe for long-term use?
Yes. Contains no synthetic drugs. 94% of clinical trial subjects showed no bleeding risks. Mild side effects (<0.5%) resolve on discontinuation.
3. Can I take it with blood thinners (e.g., aspirin)?
3. Can I take it with blood thinners (e.g., aspirin)?
❌ Avoid concurrent use. Wait ≥4 hours if prescribed anticoagulants. Consult your doctor.
4. How soon do results appear?
4. How soon do results appear?
6 weeks: Reduced fibrin deposits.
8 weeks: Measured blood viscosity improvement (18-23%).
5. Who should avoid this product?
5. Who should avoid this product?
Bleeding disorders, pregnancy, recent surgery (≤3 months), or allergy to leech-derived components.
6. Why use microcrystalline cellulose?
6. Why use microcrystalline cellulose?
Ensures delayed release to maximize absorption and minimize stomach irritation.
7. Is the nattokinase soy-free?
7. Is the nattokinase soy-free?
Yes. Japanese natto fermentation process removes soy allergens.
8. How is quality assured?
8. How is quality assured?
FDA-GMP/ISO22000 certified. Third-party tested by Harvard-affiliated labs.
9. Can diabetics use this?
9. Can diabetics use this?
Yes. Formula is sugar-free and supports microcirculation (common diabetes complication).
10. Where’s the clinical data?g
10. Where’s the clinical data?g
Full trial reports available upon request. Data complies with DSHEA guidelines.